Publications

2023

Parameter inference in a computational model of hemodynamics in pulmonary hypertension
Colunga, AL*, Colebank, MJ*,REU Program, Olufsen, MS, (*contributed equally), Accepted Jan 2023

 

 


2022

A topological data analysis study on murine pulmonary arterial trees with pulmonary hypertension
MJ Chambers , N Johnston, I Livengood, M Spinelli, R Szadanovic, MS Olufsen, Submitted Dec 2022.

 

 

A unified model of the human response to lipopolysaccharide-induced inflammation
KA Windoloski, EO Bangsgaard, A Dobreva, JT Ottesen, MS Olufsen, MS, Springer, 2022
Supplemental Material

 

Postural Orthostatic Tachycardia Syndrome explained using a baroreflex response model
J Geddes, JT Ottesen, J Mehlsen, MS Olufsen, J. R. Soc. Interface, 2022

 

 

A computational study of aortic reconstruction in single ventricle patients
AM Taylor-LaPole, MJ Colebank, JD Weigand, MS Olufsen, C Puelz, Biomech Model Mechanobiol, 2022

 

 

In Silico Modeling of Immune-Cardiovascular-Endocrine Interactions
KA Windoloski, JT Ottesen, MS Olufsen, J Cardiovasc Med Cardiol, 2022

 

 

Numerical predictions of shear stress and cyclic stretch in pulmonary hypertension due to left heart failure
Bartolo, MA, Qureshi, MU, Colebank, MJ, Chesler, NC, Olufsen, MS, Biomech Model Mechanobiol, 2022

 


2021

Coupling Vascular and Inflammatory Dynamics
KA Windoloski, MS Olfusen, SIAM News, 2021

 

 

 

 

A multiscale model of vascular function in chronic thromboembolic pulmonary hypertension
Colebank, MJ, Qureshi, MU, Rajagopal, S, Krasuski, RA, Olufsen, MS, Am J Physiol Heart Circ Physiol, 2021

 

 

Classification of orthostatic tolerance through data analytics
Gilmore, S, Hart, J, Geddes, J, Olsen, CH, Mehlsen, J, Gremaud, P, Olufsen, MS, Med Biol Eng Comput , 2021

 

 

A physiological model of the inflammatory-thermal-pain-cardiovascular interactions during a pathogen challenge
Dobreva, A, Brady, R, Larripa, K, Puelz, C, Mehlsen, J, Olufsen, MS, J Physiol, 2021
This publication is featured in The Journal of Physiology Virtual Journal Club.

 

Global sensitivity analysis informed model reduction and selection applied to a Valsalva maneuver model
Randall, EB, Randolph, NZ, Alexanderian, A, Olufsen, MS, J Theor Biol, 2021. doi: 10.1016/j.jtbi.2021.110759.

 


2020

Assessing model mismatch and model selection in a Bayesian uncertainty quantification analysis of a fluid-dynamics model of pulmonary blood circulation
Paun, L.M., Colebank, M.J., Olufsen, M.S., Hill, N.A., Husmeier, D., J Royal Soc Interface, 2020

 

Structural and hemodynamic properties of murine pulmonary arterial networks under hypoxia-induced pulmonary hypertension
Chambers, M.J., Colebank, M.J., Qureshi, M.U., Clipp, R., Olufsen, M.S., J Engineering in Medicine, 2020

 

Multi-Linear Population Analysis (MLPA) of LFP data using Tensor Decompositions
Geddes, J., Einevoll, G.T., Acar, E. and Stasik, A.J., Frontiers in Applied Mathematics and Statistics, 2020

 

 

Mechanistic model of hormonal contraception
Wright, A.A, Fayad, G, Selgrade, J, Olufsen, MS, PloS Comp Biol, 2020

 

 

Persistent instability in a nonhomogeneous delay differential equation system of the Valsalva maneuver
Randall, EB, Randolph NZ, Olufsen, MS, Math Biosci, 2020

 


Characterization of blood pressure and heart rate oscillations of POTS patients via uniform phase empirical mode decomposition
Geddes, JR, Mehlsen, J, Olufsen, MS, IEEE Trans Biomed Eng, 2020

 

Deep phenotyping of cardiac function in heart transplant patients using cardiovascular systems models
Colunga, AL, Kim, KG, Woodall, NP, Gennari, JH, Olufsen, MS, Carlson, BE, J Physiol, 2020
This publication is featured in The Journal of Physiology Journal Club.

 


2019

Influence of image segmentation on pulse wave propagation models of the pulmonary circulation
Colebank, MJ, Paun, LM, Husmeier, D, Olufsen, MS, Ellwein Fix, L, Royal Soc Interface, 2019

 


Sensitivity analysis and uncertainty quantification of 1D models of the pulmonary circulation

Colebank, M. J., Qureshi, M. U., Olufsen, M. S., Int J Number Meth Biomed Eng, 2019

 


Using modeling to predict parasympathetic and sympathetic function in response to the Valsalva maneuver

Randall, EB, Brinth, LS, Billeschou, A, Beard, DA, Mehlsen, J, Olufsen, MS, J App Physiol, 2019

 


Hemodynamic assessment of pulmonary hypertension in mice: a model-based analysis of the disease mechanism

Qureshi, MU, Colebank, MJ, Paun, M, Ellwein Fix, L, Chesler, N, Haider, MA, Hill, NA, Husmeier, D, Olufsen, MS, Biomech Model Mechanobiol, 2019

 


Cardiovascular dynamics during head-up tilt assessed via a pulsatile and non-pulsatile model

Williams, ND, Brady, R, Gilmore, S, Gremaud, P, Tran, HT, Ottesen, JT, Mehlsen, J, Olufsen, MS, J. Math Biol, 2019

 


An Optimal Control Approach for Blood Pressure Regulation during Head-Up Tilt

Williams, ND, Mehlsen, J, Olufsen, MS, Tran, HT, Biological Cybernetics, 2019

 


Parameter subset selection techniques for problems in mathematical biology

Haargaard-Olsen, C, Ottesen, JT, Smith, RC, Olufsen, MS, Biological Cybernetics, 2019

 


Cardiovascular regulation in response to multiple hemorrhages – Analysis and parameter estimation

Ciocanel, MV, Docken, SS, Gasper, RE, Dean, C, Carlson, BE, Olufsen, MS, Biological Cybernetics, 2019

 


Control theory in biology and medicine

Thomas, PJ, Olufsen, MS, Sepulchre, R, Iglesias, PA, Ijspeert, A, Scrinivasan, M, Biological Cybernetics, 2019

 


2018

Practical identifiability and uncertainty quantification of a pulsatile cardiovascular model
Marquis, AD, Arnold, A, Dean-Bernhoft, C, Carlson, BE, Olufsen, MS, Math Biosci, 2018

 


MCMC methods for inference in a mathematical model of pulmonary circulation

Paun, LM, Qureshi, MU, Colebank, M, Hill, NA, Olufsen, MS, Haider, MA, Husmeier, D, Special issue article, Statistica Neerlandica, 2018

 


Characteristic impedance: frequency or time domain approach?

Qureshi, MU, Colebank, MJ, Schreier, D, Tabina, DM, Haider, MA, Chesler, NC, Olufsen, MS, Physiological Measurements, 2018

 


Mathematical modeling of endotoxin-induced inflammatory response in young men

Brady, R, Frank-Ito, DO, Tran, HT, Janum, S, Pedersen, SB, Ottesen, JT, Mehlsen, J, Olufsen, MS, Math Modeling Natural Phenomena, 2018

 


2017

Increased blood pressure variability upon standing up improves reproducibility of cerebral auto regulation indices
Mahdi, A, Nikolic, D, Birch, DD, Olufsen, MS, Panerai, RB, Simpson, DM, Payne, SR, Med Eng Phys, 2017

 


Integrated Inflammatory Stress (ITIS) model

Bangsgaard, EO, Hjorth, PG, Olufsen, MS, Mehlsen, J, Ottesen, JT, Bull Math Bio, 2017

 


EnKF based inflow estimator for a 1D arterial network

Arnold, A, Battista, C, Bia, D, Zocalo German, Y, Armentano, RL, Tran, HT, Olufsen, MS, J Verification, Validation, and UQ, 2017

 


Modeling the differentiation of A- and C- type firing patterns in rat aortic baroreceptor

Sturdy, J, Ottesen, JT, Olufsen, MS, J Comp Neurosci, 2017

 


2016

Heterogenous mechanics of mouse pulmonary arterial network
Lee, P, Carlson, BE, Chesler, N, Olufsen, MS, Qureshi, MU, Smith, NP, Sochi, T, Beard, DA, Biotech Model Mechanobiol, 2016

 


Classification of syncope through data analytics

Hart, J, Mehlsen, J, Olsen, CH, Olufsen, M. S., Gremaud, P, arXiv preprint, 2016

 


Wave propagation in a 1D fluid dynamics model validated using pressure-area measurement from ovine arteries

Battista, C, Bia, D, Zocalo, Y, Armenian, RL, Haider, MA, Olufsen, MS, J Mech Med Biol, 2016

 


2015

Using Kalman filtering to predict time-varying parameters in a model predicting baroreflex regulation during head-up tilt
Mazurka, B, Mehlen, J, Tran, HT, Olufsen, MS, IEEE Trans Biomed Eng, 2015

 


Modeling cerebral blood flow velocity during orthostatic stress

Mader, G, Olufsen, MS, Mahdi, A, Ann Biomed Eng, 2015

 

 


2014


Structural correlation method for model reduction and practical estimation of patient specific parameters illustrated on heart rate regulation
Ottesen, JT, Mehlsen, J, Olufsen, MS, Math Biosci, 2014


Numerical simulation of blood flow and pressure drop in the pulmonary arterial and venous circulation

Qureshi, MU, Vaughan, GDA, Sainsbury, C, Johnson, M, Peskin, CS, Olufsen, MS, Hill, NA, Biotech Model Mechanobiol, 2014

 


Patient specific modeling of head-up tilt

Williams, ND, Wind-Willassen, O, Wright, AA, REU Program, Mehlsen, J, Ottesen, JT, Olufsen, MS, Math Med Biological, 2014

 


2013

Modeling the afferent dynamics of the baroreflex control system
Mahdi, A, Sturdy, J, Ottesen, JT, Olufsen, MS, PLoS Computational Biology, 2013

 


Modeling cardiovascular and respiratory dynamics in congestive heart failure

Ellweing, LM, Pope, SR, Xie, A, Batzel, JJ, Kelley, CT, Olufsen, MS, Math Biosci, 2013

 


Earlier

Simulation of rarefaction: impact on blood pressure in the systemic and pulmonary large and small arteriesOlufsen, MS, Hill, NA, Vaughan, GA, Sainsbury, C, Johnson, M, J Fluid Mech, 2012

Predicting arterial flow and pressure dynamics using a 1D fluid dynamics model with a viscoelastic wall
Steele, BN, Valdez-Jasso, D, Haider, MA, Olufsen, MS, Siam J Appl Math, 2011

Linear and nonlinear viscoelastic modeling of aorta and carotid pressure-area
Valdez-Jasso, D, Bia, D, Zocalo, Y, Armenian, RL, Haider, MA, Olufsen, MS, Ann Biomed Eng, 2011

Analysis of viscoelastic wall properties in ovine arteries
Valdez-Jasso, D, Haider, MA, Banks, HT, Bia, D, Zocalo, Y, Armentano, R, Olufsen, MS,Trans Biomed Eng, 2009

Estimation and identification of parameters in a lumped cerebrovascular modelPope, SR, Ellwein, LM, Zapata, CL, Novak, V, Kelley, CT, Olufsen, MS, Math Biosci Eng, 2009

Sensitivity analysis and model assessment: mathematical models for arterial blood flow and blood pressure
Ellwein, LM, Tran, HT, Zapata, CL, Novak, V, Olufsen, MS, Cardiovasc Eng, 2008

Modeling baroreflex regulation of heart rate during orthostatic stress
Olufsen, MS, Tran, HT, Ottesen, JT, REU Program, Lipsitz, LA, Novak, V, Am J Physiol, 2006

Blood Pressure and blood flow variation during postural change from sitting to standing – Mathematical modeling and experimental validation
Olufsen, MS, Ottesen, JT, Tran, HT, Ellwein, LM, Lipsitz, LA, Novak, V,
J Appl Physiol, 2005

Mathematical Modeling in Human Physiology
Ottesen, JT, Olufsen, MS, Larsen, JK, SIAM, Philadelphia, 2004

A lumped parameter model for cerebral blood flow regulation
Olufsen, MS, Lipsitz, LA, Nadim, A, Advances in Bioengineering, 2001

Numerical simulation and experimental validation of blood flow in arteries with structured-tree outflow conditions
Olufsen, MS, Peskin, CS, Kim, WY, Pedersen, EM, Nadim, A, Larsen, J,
Ann Biomed Eng, 2000