Autonomic Dysfunction

Team: Justen Geddes & Mette Olufsen
Collaborators:
Brian Carlson (University of Michigan), Jesper Mehlsen (Rigshospitalet, Denmark), Johnny Ottesen (Roskilde University)

Recent Publications:

  1. A model-based analysis of autonomic nervous function in response to the Valsalva maneuver
    EB Randall, A Billeschou, LS Brinth, J Mehlsen, MS Olufsen
    Journal of Applied Physiology 127, 2019
  2. Global sensitivity analysis informed model reduction and selection applied to a Valsalva maneuver model
    EB Randall, NZ Randolph, A Alexanderian, MS Olufsen
    Journal of Theoretical Biology 2021

Overview:
The cardiovascular system as a whole is controlled both neurally and hormonally, maintaining homeostasis. In our work, we model the reflexive neurological control systems governing blood pressure and heart rate. Primarily, we focus on the autonomic nervous system (ANS), which involuntarily controls vital bodily functions (e.g., breathing, heart rate, blood pressure, pupil dilation, etc.). When these systems do not function normally, the body suffers from ANS dysfunction can arise idiopathically or in conjunction with several diseases and disorders (e.g., Parkinson's disease, diabetes, etc.). Our goal is to understand the physiological differences between the healthy and disease states to (i) quantify these changes in cardiovascular function, (ii) detect early biomarkers for ANS dysfunction, and (iii) provide plausible hypotheses contributing to the dysfunction.

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