Team: Kristen Windoloski1, Mette Olufsen11, Ronan Berg2, Johnny Ottesen3, Atanaska Dobreva4

Affiliations: NC State University1, University of Copenhagen2, Roskilde University3, Augusta University4

Recent Publications: 

  1. A unified model of the human response to lipopolysaccharide-induced inflammation
    KA Windoloski, EO Bangsgaard, A Dobreva, JT Ottesen, MS Olufsen, MS
    Springer, 2022
  2. In Silico modeling of immune-cardiovascular-endocrine interactions
    KA Windoloski, JT Ottesen, MS Olufsen
    Journal of Cardiovascular Medicine, 2022
  3. Coupling Vascular and Inflammatory Dynamics
    KA Windoloski, MS Olufsen
    SIAM News, 2021
  4. A physiological model of the inflammatory-thermal-pain-cardiovascular interactions during a pathogen challenge
    Dobreva, A, Brady, R, Larripa, K, Puelz, C, Mehlsen, J, Olufsen, MS,
    The Journal of Physiology, 2021
  5. Mathematical modeling of endotoxin-induced inflammatory response in young men and associated changes in heart rate variability
    Brady, R, Frank-Ito, DO, Tran, HT, Janum, S, Pedersen, SB, Ottesen, JT, Mehlsen, J, Olufsen, MS
    Math Modeling Natural Phenomena, 2018

Summary: A systemic inflammatory response is a hallmark of individuals with sepsis, which is a leading cause of death in the U.S. hospitals. A common, short-term inflammation model consists of administering a bolus dose of endotoxin to healthy volunteers. Previous work in our group focused on creating a dynamic mathematical model fit to experimental data to describe the immune response to a bolus administration of endotoxin along with its implications on the cardiovascular system, regulation body temperature, and perception of pain. However, illnesses like sepsis are better described by a long-term inflammation model, where inflammatory stimuli are present in the body for longer periods of time. Therefore, our current and future work is focused on adapting the bolus-dose inflammatory response model described above, which tracks selected cytokines and immune cells, to capture the dynamic inflammatory response to a continuous infusion of endotoxin over an extended period of time. Results from this particular work can then be used to further study inflammatory-cardiovascular relations during conditions such as sepsis, including estimating sepsis cardiac biomarkers and studying treatment methods for sepsis patients.


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